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rt112/84  (CancerTools Org)


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    CancerTools Org rt112/84
    Rt112/84, supplied by CancerTools Org, used in various techniques. Bioz Stars score: 99/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rt112/RT112%2F84/custom%40153250%4010%2E64898%2F2026%2E10%2E05%2E756638
    Average 99 stars, based on 13 article reviews
    rt112/84 - by Bioz Stars, 2026-11
    99/100 stars

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    Related Articles

    Cell Culture:

    Article Title: A novel quinoline and manganese-based carbon monoxide-releasing molecule for intravesical therapy of bladder cancer.
    Article Snippet: Funding information Jiaxing Medical Key Subject Funding of Zhejiang Province, Grant/Award Number: 2023-ZC-013; the Jiaxing Key Laboratory of Precise Diagnosis and Treatment of Urological Tumor, Grant/Award Number: 2020-mnzdsys; National Natural Science Foundation of China, Grant/Award Number: 82104197; Natural Science Foundation of Zhejiang Province, Grant/Award Number: LY23B010002; Jiaxing University, Grant/Award Number: CD70623036 Abstract Background and Purpose: Bladder cancer remains a significant burden on public health globally.. Carbon monoxide (CO) has emerged as a promising therapeutic agent for cancers because of its key role in inducing mitochondrial dysfunction and metabolic reprogramming in cancer cells; however, its clinical translation has been hindered by systemic toxicity because of its binding to haemoglobin, which is avoided by localised intravesical therapy via the bladder.. This study aimed to develop and characterise a novel manganese(I)-based CO releasing molecular MnCORM as a therapeutic agent against bladder cancer.



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    Effect of berbamine on 5-ALA-induced PpIX accumulation. RT112, RT112 LTT, RT112 CSC (top), and J82, J82 LTT, J82 CSC (bottom) were treated with 5-ALA (0–100 µg/ml) and berbamine (no, ½ IC 50 , IC 50 ). PpIX fluorescence intensity was normalized to cell viability and is shown as individual values with mean as a line. Asterisks indicate significance compared to the sample without berbamine (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Journal: Scientific Reports

    Article Title: Combining 5-ALA-PDT with berbamine as an in vitro multimodal therapy approach against bladder cancer cells

    doi: 10.1038/s41598-026-46092-x

    Figure Lengend Snippet: Effect of berbamine on 5-ALA-induced PpIX accumulation. RT112, RT112 LTT, RT112 CSC (top), and J82, J82 LTT, J82 CSC (bottom) were treated with 5-ALA (0–100 µg/ml) and berbamine (no, ½ IC 50 , IC 50 ). PpIX fluorescence intensity was normalized to cell viability and is shown as individual values with mean as a line. Asterisks indicate significance compared to the sample without berbamine (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Article Snippet: RT112 (DSMZ, cat. no. ACC-418) and J82 (ATCC, cat. no. HTB-1) cell lines originate from transitional cell carcinoma of the human bladder.

    Techniques: Fluorescence

    Cell viability of RT112, RT112 LTT and RT112 CSC following 5-ALA-PDT treatment with increasing irradiation doses and varying concentrations of 5-ALA and berbamine. Bars represent weighted means ± SD from three independent experiments ( n = 3 × 6; controls without irradiation n = 3 × 36). Asterisks indicate significance of unweighted means compared to the irradiated control sample without 5-ALA C1.1-C1.4 (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Journal: Scientific Reports

    Article Title: Combining 5-ALA-PDT with berbamine as an in vitro multimodal therapy approach against bladder cancer cells

    doi: 10.1038/s41598-026-46092-x

    Figure Lengend Snippet: Cell viability of RT112, RT112 LTT and RT112 CSC following 5-ALA-PDT treatment with increasing irradiation doses and varying concentrations of 5-ALA and berbamine. Bars represent weighted means ± SD from three independent experiments ( n = 3 × 6; controls without irradiation n = 3 × 36). Asterisks indicate significance of unweighted means compared to the irradiated control sample without 5-ALA C1.1-C1.4 (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Article Snippet: RT112 (DSMZ, cat. no. ACC-418) and J82 (ATCC, cat. no. HTB-1) cell lines originate from transitional cell carcinoma of the human bladder.

    Techniques: Irradiation, Control

    Berbamine has cytotoxic effects in ROS generation, cell migration and apoptosis rate for cisplatin-resistant cell lines RT112 LTT and J82 LTT. Tert-butyl hydroperoxide (TBHP; 150 µM) served as positive control for determination of reactive oxygen species (ROS). Detailed data presentation for all cell lines are available in the supplementary section (Supplementary Figs. , and ). Data represent mean ± SD ( n = 3). Asterisks indicate significance relative to the control without berbamine (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Journal: Scientific Reports

    Article Title: Combining 5-ALA-PDT with berbamine as an in vitro multimodal therapy approach against bladder cancer cells

    doi: 10.1038/s41598-026-46092-x

    Figure Lengend Snippet: Berbamine has cytotoxic effects in ROS generation, cell migration and apoptosis rate for cisplatin-resistant cell lines RT112 LTT and J82 LTT. Tert-butyl hydroperoxide (TBHP; 150 µM) served as positive control for determination of reactive oxygen species (ROS). Detailed data presentation for all cell lines are available in the supplementary section (Supplementary Figs. , and ). Data represent mean ± SD ( n = 3). Asterisks indicate significance relative to the control without berbamine (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

    Article Snippet: RT112 (DSMZ, cat. no. ACC-418) and J82 (ATCC, cat. no. HTB-1) cell lines originate from transitional cell carcinoma of the human bladder.

    Techniques: Migration, Positive Control, Control